Medically the review by Femi Aremu, PharmD — created by university of Illinois-Chicago, drug Information team — update on October 16, 2020
Trazodone oral tablet computer is easily accessible as a generic drug. That doesn’t have actually a brand-name version.Trazodone only comes together a tablet you take by mouth.Trazodone is used to act depression.

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Trazodone oral tablet is a prescription drug. It’s obtainable only together a share drug. Generic medicine usually price less than brand-name drugs.

Why the used

Trazodone is supplied to law depression in adults.

How it works

Trazodone belongs come a class of drugs referred to as antidepressants. A course of drugs is a team of medications that work in a comparable way. These drugs are frequently used to treat comparable conditions.

It isn’t fully understood just how trazodone works. The may increase serotonin task in your brain. Serotonin is a chemistry in your mind that can help stabilize your mood.

Trazodone oral tablet computer may reason drowsiness or sleepiness. You do not do it drive, use machinery, or execute other activities that call for alertness until you know just how this drug affects you.


Trazodone next effects

Trazodone can reason mild or major side effects. The complying with list has some of the crucial side effects that may happen while acquisition trazodone. This perform does not include all feasible side effects.

For an ext information ~ above the feasible side impacts of trazodone, or tips on how to attend to a troubling next effect, talk with your physician or pharmacist.

More usual side effects

The much more common side impacts of trazodone deserve to include:

swellingsleepinessdizzinessdiarrheastuffy noseweight lossblurred vision

These effects may walk away in ~ a couple of days or a couple of weeks. If they’re more severe or don’t go away, talk to your medical professional or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Speak to 911 if her symptoms feeling life threatening or if you think you’re having actually a clinical emergency. Serious side effects and also their symptom can include the following:

Thoughts the suicide and worsening depression. Symptom include: thoughts around suicide or dyingattempts to dice by suicidenew or worse depressionnew or worse anxietyfeeling an extremely agitated or restlesspanic attacksinsomnia (trouble sleeping)new or worse irritabilityacting aggressive, angry, or violentacting on dangerous impulsesmania (an too much increase in task and talking)other unusual alters in actions or mood Serotonin syndrome. Symptoms include: agitationconfusion or trouble thinkinghallucinations (seeing or listening something that isn’t there)problems through coordinationfast heart ratetight musclestrouble walkingnauseavomitingdiarrhea Vision problems. Symptom include: eye painchanges in her vision, such together blurred vision or intuitive disturbancesswelling or redness in or roughly your eye rarely often, rarely or rapid heartbeatLow blood pressure. Symptom include: dizziness or fainting when you adjust positions, such as standing increase from a sitting place Unusual bruising or bleedingErection that lasts longer than 4 hoursHyponatremia (low sodium in her blood). Symptoms include: headacheweaknessconfusiontrouble concentratingmemory problemsfeeling unsteady once you to walk

The trazodone dosage your medical professional prescribes will count on various factors. These include:

the form and severity of the condition you’re using the drug to treatyour agethe form of the drug you takeother medical conditions you may have

Typically, your doctor will begin you on a low dosage and adjust it over time to with the dosage that’s best for you. They’ll at some point prescribe the the smallest dosage that gives the wanted effect.

The complying with information explains dosages that are commonly used or recommended. However, be certain to take it the dosage your medical professional prescribes because that you. Your doctor will identify the best dosage to suit your needs.

Forms and strengths

Generic: Trazodone

Form: oral tabletStrengths: 50 mg, 100 mg, 150 mg, 300 mg

Dosage for significant depressive disorder

Adult dosage (ages 18 years and older)

Typical beginning dosage: 150 mg per day in split doses.Dosage increases: Your medical professional may rise your dose by 50 mg every day every 3 or 4 days.Maximum dosage: 400 mg per day in divided doses. If you’re continuing to be in a hospital, the maximum dosage is 600 mg per day.

Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children. It shouldn’t be offered in human being younger 보다 18 years old.


Trazodone oral tablet computer is supplied for permanent treatment. It comes v serious dangers if girlfriend don’t take it it as prescribed.

If you prevent taking the drug or don’t take it it at all. If you prevent taking this drug all of sudden or don’t take it it, your depression may not obtain better. Friend may additionally have tap the money symptoms. These incorporate anxiety, agitation, and trouble sleeping. If you must stop taking this drug, your physician will progressively lower her dose over time.

If you miss out on doses or don’t take the medicine on schedule. your medication might not work too or may stop functioning completely. Because that this medicine to work well, a certain amount needs to it is in in your body at all times.

If friend take too much. You might have dangerous levels of trazodone in her body. Symptom of one overdose the this drug have the right to include:

an erection that lasts much longer than 4 hoursseizureschanges in the method your heart functions, including QT prolongation (a heart rhythm worry that may cause chaotic or abnormal heartbeats)

If friend think you’ve taken too much of this drug, contact your doctor or seek guidance native the American association of Poison manage Centers in ~ 800-222-1222 or through their virtual tool. But if your symptoms are severe, contact 911 or walk to the nearest emergency room best away.

What to do if you miss out on a dose. Take your dose as quickly as you remember. But if friend remember just a couple of hours prior to your next scheduled dose, take only one dose. Never try to catch up by taking two doses in ~ once. This could result in dangerous next effects.

How come tell if the medicine is working. You must have lessened feelings the depression, and your mood must improve.


This drug comes with miscellaneous warnings.

Serotonin syndrome warning

This drug can reason a life threatening condition called serotonin syndrome. This threat is higher when you an initial start taking this drug or throughout dosage changes.

Your risk may be greater if you likewise take other drugs that have similar effects together trazodone, together as other drugs provided to treat depression.

Symptoms that serotonin syndrome incorporate agitation, hallucinations, confusion or trouble thinking, nausea, vomiting, and also diarrhea.

They also include coordination problems, muscle twitching, stubborn muscles, racing heart rate, high or short blood pressure, sweating, fever, and coma.

Call your doctor right far if you have these symptoms.

Angle-closure glaucoma warning

This drug can cause your pupils to be contempt bigger and also lead to angle-closure glaucoma (a condition that reasons increased push in her eyes). If you’re in ~ high threat for this condition, your doctor may offer you a medication to assist prevent it.

Bleeding warning

Taking this drug through other medicines that influence your capacity to prevent bleeding may increase your danger for bleeding. This consists of serious, life threaten bleeding, and also bleeding-related events, such as nosebleeds, bruising, or skin discoloration due to bleeding listed below your skin.

These drugs incorporate warfarin, dabigatran, rivaroxaban, and pain medications dubbed nonsteroidal anti-inflammatory medicine (NSAIDs), such together ibuprofen and also aspirin.

Allergy warning

Trazodone can reason a serious allergic reaction. Symptoms have the right to include:

trouble breathingswelling of your face, tongue, eyes, or mouthrash, hives (itchy welts), or blisters, alone or v fever or joint pain

If you have an allergic reaction, contact your doctor or neighborhood poison control facility right away. If her symptoms are severe, call 911 or walk to the nearest emergency room.

Don’t take this drug again if you’ve ever before had an allergic reaction to it. taking it again could be deadly (cause death).

Alcohol communication warning

Consuming drink that contain alcohol deserve to increase your danger for sleepiness or dizziness native trazodone. If friend drink alcohol, talk to her doctor about whether alcohol use is safe for girlfriend while you take this drug.

Warnings for civilization with specific health conditions

For world with heart disease. ask your doctor whether this medicine is for sure for you. Acquisition trazodone may reason irregular heartbeat and a lengthy QT interval (a love rhythm problem that may reason chaotic or abnormal heart beats). Her doctor might watch you carefully if you take it this drug.

For human being with angle-closure glaucoma. This drug may make your pupils bigger and also may cause an angle-closure attack.

For people with a history of mania or bipolar disorder. friend may have a higher risk because that manic episodes. If you have actually a background of mania or bipolar disorder, your doctor might need come prescribe a different medication.

Warnings for various other groups

For pregnant women. There haven’t been sufficient studies excellent in people to be particular how this medicine might affect a pregnancy.

Research in animals has shown negative effects come the fetus as soon as the mother takes this drug. However, animal studies don’t constantly predict the means humans would respond.

Talk to your physician if you pregnant or to plan to become pregnant. This drug should only be supplied if the potential advantage justifies the potential hazard to the fetus. Contact your doctor right far if you end up being pregnant while taking this drug.

There’s a pregnant exposure registry that monitors pregnant outcomes in females exposed come antidepressants throughout pregnancy. Come take component in the national Pregnancy Registry for Antidepressants, call 844-405- 6185 or visit your website.

Women who room breastfeeding. Trazodone may pass right into breast milk and also may cause side impacts in a son who is breastfed. Talk to your medical professional if you breastfeed your child. You might need to decision whether to protect against breastfeeding or protect against taking this medication.

For seniors. The kidney of enlarge adults might not work and they used to. This can reason your human body to process drugs an ext slowly. As a result, an ext of a drug continues to be in your body because that a longer time. This raises your hazard of side effects.

If you’re end the age of 65 years, you may be at greater risk for developing side impacts while acquisition this drug. This has hyponatremia (low salt level in her blood).

For children. The safety and effectiveness that this drug haven’t been established in children. This drug shouldn’t be provided in human being younger 보다 18 years.


Trazodone oral tablet can interact with several other medications. Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while rather can reason increased next effects.

Below is a list of medicines that can connect with trazodone. This list does no contain all drugs that may interact with trazodone.

Before acquisition trazodone, be certain to tell your doctor and also pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements friend use. Sharing this info can assist you stop potential interactions.

If you have questions about drug interactions the may impact you, ask your physician or pharmacist.

Drugs you should not use through trazodone

Do not take these drugs v trazodone. Doing therefore can reason dangerous effects in her body. Instances of this drugs include:

Monoamine oxidase inhibitors (MAOIs), such together isocarboxazid, phenelzine, tranylcypromine, or selegiline. friend shouldn’t take trazodone v MAOIs or in ~ 14 work of acquisition them. Acquisition these drugs with each other raises your threat for serotonin syndrome.

Interactions that can cause much more side effects

Taking trazodone with details medications might cause more side effects. This drugs include:

Central nervous system (CNS) depressants such as pentobarbital and secobarbital. Trazodone may make your solution to barbiturates and other CNS depressants stronger.Warfarin. taking trazodone v warfarin have the right to increase your danger for bleeding. Your doctor will watch you closely.Nonsteroidal anti-inflammatory medicine (NSAIDs) or aspirin. Trazodone may boost your hazard of bleeding when offered with these drugs.Depression drugs, such as citalopram, fluoxetine, paroxetine, sertraline, venlafaxine, duloxetine, and also St. John’s wort. acquisition these drugs with each other may rise your threat of serotonin syndrome. This problem can be life threatening.Digoxin. taking trazodone v digoxin may rise the level of digoxin in her body. This could increase your danger of side results from digoxin. These incorporate vomiting, dizziness, vision problems, and irregular heart rate. Her doctor may monitor the level the digoxin in your blood if you take it these drugs together.Phenytoin. taking trazodone through phenytoin may rise the level of phenytoin in your body. This might increase your hazard for side impacts from phenytoin. These encompass constipation, changes in mood, confusion, and balance problems. Your doctor might monitor the level the phenytoin in her blood if you take it these medicine together.Ketoconazole or ritonavir. The level that trazodone in your body may increase if you take it v ketoconazole, ritonavir, or other drugs that boost levels that trazodone. This can increase your danger of side effects from trazodone. These incorporate serotonin syndrome and vision problems. Your doctor may reduced your trazodone dosage if you take it drugs that can increase trazodone levels.

Interactions that can make drugs less effective

Certain drugs might decrease the level of trazodone in her body and also make your dosage that trazodone much less effective. Friend doctor may need to boost your dosage that trazodone as soon as you take it with these drugs.

These medicine include:

Phenytoin and carbamazepine

Keep this considerations in mind if your physician prescribes trazodone oral tablet computer for you.

General

Take trazodone shortly after a meal or snack.You have to swallow this medicine whole. Friend can also break it in fifty percent along the score heat (indented line down the facility of the tablet) and also swallow it. Nothing chew or crush trazodone tablets.

Storage

Store trazodone at room temperature. Keep it in between 68°F and 77°F (20°C and 25°C).Keep it away from light.

Refills

A prescription because that this medication is refillable. You need to not need a brand-new prescription because that this medicine to it is in refilled. Your medical professional will write the number of refills authorized on her prescription.

Travel

Always lug your medication v you. When flying, never ever put it right into a checked bag. Save it in your carry-on bag.Don’t worry about airport X-ray machines. They can’t hurt your medication.You might need to present airport employee the pharmacy label for her medication. Always carry the original prescription-labeled box with you.Don’t placed this medicine in your car’s glove compartment or leave it in the car. Be certain to protect against doing this once the weather is an extremely hot or an extremely cold.

Clinical monitoring

You and your doctor have to monitor certain health issues. This can assist make certain you remain safe when you take this drug. These worries include:

Eye health. You might be at danger for angle-closure glaucoma. Your doctor may do one eye exam and also treat friend if needed.Mental health and behavioral problems. You and your doctor must watch for any type of changes in her behavior and also mood. This drug have the right to cause new mental health and behavior issues. That can additionally make troubles you already have worse.

Prior authorization

Many insurance companies might require a prior authorization because that this drug. This way your physician will require to acquire approval from her insurance agency before your insurance company will pay because that the prescription.


There are other drugs available to treat your condition. Some might be much better suited because that you 보다 others. Talk to your doctor around other drug alternatives that may work because that you.

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